Acetyl chloride → Methyl 4-Amino-2-chlorobenzoate

HRID 220851

반응식

HRID 220851 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([Cl:11])[CH:3]=1.[C:12](Cl)(=O)C>CO>[CH3:12][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[CH:3][C:4]=1[Cl:11]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 171544-Amino-2-chlorobenzoic acid

생성물 1

HCID 11839197Methyl 4-Amino-2-chlorobenzoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 4-Amino-2-chloro-benzoic acid (5.3 g, 31 mmol) in methanol (100 ml) was treated with acetyl chloride (5 ml) and then heated at reflux for 16 hours. The solvents were evaporated in vacuo. The residue was dissolved in EtOAc, washed with saturated sodium hydrogen carbonate, dried and concentrated in vacuo to yield the title compound as a purple solid, 5.45 g, 95%.

후처리

  1. temperatureheated
  2. temperatureat reflux for 16 hours
  3. customThe solvents were evaporated in vacuo
  4. dissolutionThe residue was dissolved in EtOAc
  5. washwashed with saturated sodium hydrogen carbonate
  6. customdried
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-54db863b2afa414085e0648f08ae77ca
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202858B2

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