Acetyl chloride → Methyl 4-Amino-2-chlorobenzoate
반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([Cl:11])[CH:3]=1.[C:12](Cl)(=O)C>CO>[CH3:12][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[CH:3][C:4]=1[Cl:11]참가 물질
4
실험 절차
A solution of 4-Amino-2-chloro-benzoic acid (5.3 g, 31 mmol) in methanol (100 ml) was treated with acetyl chloride (5 ml) and then heated at reflux for 16 hours. The solvents were evaporated in vacuo. The residue was dissolved in EtOAc, washed with saturated sodium hydrogen carbonate, dried and concentrated in vacuo to yield the title compound as a purple solid, 5.45 g, 95%.
후처리
- temperatureheated
- temperatureat reflux for 16 hours
- customThe solvents were evaporated in vacuo
- dissolutionThe residue was dissolved in EtOAc
- washwashed with saturated sodium hydrogen carbonate
- customdried
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-54db863b2afa414085e0648f08ae77ca
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08202858B2
반응 노트
불러오는 중…