Methyl iodide → 5-Bromo-1,2-dimethyl-3-nitrobenzene
반응식
[Br:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=O.C(=O)([O-])[O-].[Na+].[Na+].CI>CN(C=O)C>[CH3:7][C:6]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]=1[CH3:11]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a stirred solution of 5-bromo-2-methyl-3-nitrobenzoic acid (287 g, 1103 mmol) in DMF (150 mL), sodium carbonate (468 g, 4415 mmol) and methyl iodide (626.63 g, 4415 mmol) were added. Resulting reaction mass was heated at 60° C. for 8 h. On completion, solid precipitated was filtered, residue washed with diethyl ether (5 times). Combined organic layers were dried, concentrated under reduced pressure giving the desired compound (302 g, 99%) which was used for further reaction.
후처리
- customResulting
- customreaction mass
- customOn completion, solid precipitated
- filtrationwas filtered
- washresidue washed with diethyl ether (5 times)
- customCombined organic layers were dried
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-878164394f97489d80a3f9fe3f7903b7
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09376422B2
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