Methyl iodide → 5-Bromo-1,2-dimethyl-3-nitrobenzene
반응식
[Br:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=O.C(=O)([O-])[O-].[Na+].[Na+].CI>CN(C=O)C>[CH3:7][C:6]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]=1[CH3:11]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To stirred solution of 5-bromo-2-methyl-3-nitrobenzoic acid, prepared analogously to above, (287 g, 1103 mmol) in DMF (150 mL), sodium carbonate (468 g, 4415 mmol) and methyl iodide (626.6 g, 4415 mmol) were added. Resulting mixture was heated at 60° C. for 8 h. On completion, solid was remove by filtration, and the residue washed with diethyl ether (5 times). The combined organic layers were dried, concentrated under reduced pressure to give methyl 5-bromo-2-methyl-3-nitrobenzene (302 g, 99%).
후처리
- customResulting mixture
- customOn completion, solid was remove by filtration
- washthe residue washed with diethyl ether (5 times)
- customThe combined organic layers were dried
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-9104854ee5da4a6eb6955f0e39a2cc11
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09376422B2
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