Methyl iodide → 5-Bromo-1,2-dimethyl-3-nitrobenzene
반응식
[Br:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=O.C(=O)([O-])[O-].[Na+].[Na+].CI>CN(C=O)C>[CH3:7][C:6]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]=1[CH3:11]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a stirred solution of 5-bromo-2-methyl-3-nitrobenzoic acid (287 g, 1100 mmol) in DMF (150 mL), were added sodium carbonate (468 g, 4415 mmol) and methyl iodide (627 g, 4415 mmol). The mixture was heated at 60° C. for 8 h. The precipitate was filtered and washed with diethyl ether (5 times). The combined organic layers were dried, concentrated under reduced pressure giving the title compound (302 g, 99%) which was used directly without further purification.
후처리
- filtrationThe precipitate was filtered
- washwashed with diethyl ether (5 times)
- customThe combined organic layers were dried
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-1b8b8c030ea543b8b0eb36058fca9760
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09376422B2
반응 노트
불러오는 중…