Methyl iodide → Benzoic acid, 5-methoxy-2-methyl-3-nitro-, methyl ester

HRID 2208917노트

반응식

HRID 2208917 반응식
[OH:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5](C)=[C:6]([CH:10]=1)C(O)=O.[C:15](=O)([O-])[O-].[Na+].[Na+].CI.[C:23]([O:26][CH2:27]C)(=[O:25])[CH3:24]>CN(C=O)C.O>[CH3:15][O:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:6])=[C:24]([CH:10]=1)[C:23]([O:26][CH3:27])=[O:25]

참가 물질

7

반응물 4

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 10340Sodium CarbonateHCID 23009717HCID 23009717, 화합물

생성물 1

HCID 53399479Benzoic acid, 5-methoxy-2-methyl-3-nitro-, methyl ester

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

To a stirred solution of 5-hydroxy-2-methyl-3-nitrobenzoic acid (1.50 g, 7.61 mmol) in DMF (15 mL) was added sodium carbonate (3.23 g, 30.5 mmol) and methyl iodide (1.88 mL, 30.5 mmol). The resulting reaction mixture was heated at 60° C. for 8 h. On completion, the reaction mixture was diluted with water and extraction was carried out using ethyl acetate. The combined organic layers were dried and concentrated under reduced pressure to give the crude title compound (1.7 g) which was used directly in the next step.

후처리

  1. customThe resulting reaction mixture
  2. customThe combined organic layers were dried
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e5fa4c38e4e94694965a113c9df36cac
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09376422B2

반응 노트

불러오는 중…