Sodium Hydroxide → 4-[4-[4-(4-Pyridyl)piperazin-1-yl]phenoxy]butyric acid

HRID 2209

반응식

HRID 2209 반응식
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[OH-:20].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:13][CH2:14][CH2:15][C:16]([OH:19])=[O:20])=[CH:15][CH:14]=3)[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 149869034-(4-(4-Pyridyl)piperazin-1-yl)phenol

생성물 1

HCID 189185114-[4-[4-(4-Pyridyl)piperazin-1-yl]phenoxy]butyric acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of the product of Example 25 (0.1 g) in aqueous sodium hydroxide (1N, 0.8 ml) and ethanol (2 ml) was kept for 2 hours. The solution was evaporated and the residue dissolved in water (5 ml). Hydrochloric acid (1N, 0.8 ml) was added and the precipitate was filtered and washed with water and ether to give the title compound as a solid: m.p 305°-306° C.; m/e 342(M+H)+ ; NMR(d6DMSO) δ 8.0(2H,d); 6.72(6H,m); 3.74(2H,t); 3.3(4H,m); 2.94(4H,m); 2.19(2H,t); 1.72(2H, m); calculated for C19H23N3O3 : C, 66.8; H, 6.8; N, 12.3. Found: C, 67.0; H, 6.8; N, 12.2%.

후처리

  1. customThe solution was evaporated
  2. dissolutionthe residue dissolved in water (5 ml)
  3. additionHydrochloric acid (1N, 0.8 ml) was added
  4. filtrationthe precipitate was filtered
  5. washwashed with water and ether

출처 및 근거

ORD 기록
ord-f32c2189fde44a52a00908f735c49175
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728701

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