Benzene → Nonivamide

HRID 2209912

반응식

HRID 2209912 반응식
Cl.[OH:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][NH2:8])=[CH:5][C:4]=1[O:11][CH3:12].C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+].[C:25](Cl)(=[O:34])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]>O>[CH3:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][C:25]([NH:8][CH2:7][C:6]1[CH:9]=[CH:10][C:3]([OH:2])=[C:4]([O:11][CH3:12])[CH:5]=1)=[O:34]

참가 물질

6

반응물 4

HCID 241BenzeneHCID 11430Potassium CarbonateHCID 69819Nonanoyl chlorideHCID 165576Phenol, 4-(aminomethyl)-2-methoxy-, hydrochloride (1:1)

생성물 1

HCID 2998Nonivamide

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

58.5 parts of 4-hydroxy-3-methoxybenzylamine hydrochloride, 200 parts of benzene and 200 parts of water were charged into a reaction vessel equipped with a three-one motor the rotational frequency of which is variable and an outlet having a stopper at the bottom portion and stirred. 58 parts of potassium carbonate was added to the mixture and further 54 parts of pelargonoyl chloride was added dropwise to a resultant mixture at room temperature. In this state, the mixture was stirred for 3 hours until the end of the reaction. After the stirring was stopped and the mixture was allowed to stand for 30 minutes, the water layer in the lower layer was discharged from the bottom portion. The residue was distilled under a reduced pressure to remove solvent almost completely, thereby obtaining crude nonylic acid vanillylamide. As a result of quantitative analysis of a slight amount of product by HPLC, the purity of nonylic acid vanillylamide was determined to be 92.1%. The irritant nature thereof to skin, especially, to mucose was strong.

후처리

  1. customequipped with a three-one motor the rotational frequency of which
  2. customan outlet having
  3. stirringIn this state, the mixture was stirred for 3 hours until the end of the reaction
  4. distillationThe residue was distilled under a reduced pressure
  5. customto remove solvent almost completely

출처 및 근거

ORD 기록
ord-ade341d2c2424298981ecf20d1ba0549
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05456916

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