Acetic Anhydride → 6-Acetamido-4-(3'-trifluoromethylanilino)quinazoline

반응식

[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:21])([F:22])[F:20])[CH:14]=1)(=[O:25])[CH3:24]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 53281884-N-[3-(trifluoromethyl)phenyl]quinazoline-4,6-diamine

생성물 1

HCID 199632086-Acetamido-4-(3'-trifluoromethylanilino)quinazoline수율 87%

실험 절차

Using an analogous procedure to that described in Example 11, 6-amino-4-(3'-trifluoromethylanilino)quinazoline was reacted with acetic anhydride to give 6-acetamido-4-(3'-trifluoromethylanilino)quinazoline in 87% yield as a solid.

출처 및 근거

ORD 기록: ord-84a3a3bd73e74384946fce95f05951b1
출처 데이터셋: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05457105

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