Phthalic Acid → 4-[3-(2-Carboxybenzoylamino)propylthio]pyridine

HRID 2210121

반응식

HRID 2210121 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1.[C:12](O)(=[O:22])[C:13]1[C:14](=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:15]([OH:17])=[O:16]>C(Cl)Cl>[C:15]([C:14]1[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=1[C:12]([NH:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)=[O:22])([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 1017Phthalic AcidHCID 152276954-(3-Aminopropylthio)pyridine

생성물 1

HCID 190791084-[3-(2-Carboxybenzoylamino)propylthio]pyridine수율 92.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 340 mg (2.02 mmol) of 4-(3-aminopropylthio)pyridine and 738 mg (4.98 mmol) of anhydrous phthalic acid in 5 ml of methylene chloride was stirred at room temperature for 30 minutes. The resulting crystals were filtered and dried to obtain 590 mg of the desired compound (92.3%, colorless powder), mp: 151.0°-153.3° C.

후처리

  1. filtrationThe resulting crystals were filtered
  2. customdried

출처 및 근거

ORD 기록
ord-7a3ff4c3da6d4209a50b11a20382f399
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05457106

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