Sodium Hydroxide → [(3,4,4-Trifluoro-3-butenyl)amino]oxoacetic acid
반응식
O=[C:2]([NH:9][C:10](=[O:15])[C:11]([O:13]C)=[O:12])[CH2:3][C:4]([F:8])=[C:5]([F:7])[F:6].[OH-].[Na+]>CO.O>[F:8][C:4](=[C:5]([F:6])[F:7])[CH2:3][CH2:2][NH:9][C:10](=[O:15])[C:11]([OH:13])=[O:12]참가 물질
5
실험 절차
A solution of Compound 142 (3.16 g, 0.015 mole) in methanol (25 mL) is treated with a solution of NaOH (0.8 g, 0.02 mole) in water (5 mL). The solution is stirred at room temperature for 30 min and concentrated. The residue is dissolved in water (20 mL) and extracted with dichloromethane (2×30 mL). The aqueous layer is acidified with conc. HCl and extracted with ethyl acetate. The organic layer is dried and evaporated to give 0.75 g of the title compound as a white solid, a 25% yield. m.p. 95°-100° C.
후처리
- concentrationconcentrated
- dissolutionThe residue is dissolved in water (20 mL)
- extractionextracted with dichloromethane (2×30 mL)
- extractionextracted with ethyl acetate
- customThe organic layer is dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-b2c79e2c2a434b108e30ccbc6651f160
- 출처 데이터셋
- uspto-grants-1995_10
- 특허 번호
- US05457134
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