Sulfuric Acid → 2,3-Dihydro-1H-indole-7-carboxylic acid
반응식
[C:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH2:9][CH2:8]2)#N.[OH-:12].[Na+].S(=O)(=O)(O)[OH:15]>>[NH:10]1[C:11]2[C:7](=[CH:6][CH:5]=[CH:4][C:3]=2[C:1]([OH:15])=[O:12])[CH2:8][CH2:9]1참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
A mixture of 7-cyanoindoline (4.32 g) and 50% aqueous sulfuric acid (40 ml) was stirred at 110°-120° C. for 5.5 hours, cooled to 5° C. and adjusted to pH 7-8 with 24% aqueous sodium hydroxide. The mixture was washed with ethyl acetate and the aqueous layer was adjusted to pH 2.5-3.0 with 6N hydrochloric acid. The precipitates were collected by filtration to give indoline-7-carboxylic acid (3.25 g).
후처리
- washThe mixture was washed with ethyl acetate
- filtrationThe precipitates were collected by filtration
출처 및 근거
- ORD 기록
- ord-bc385e5d9d7b4eb5a78b5c4c1de3a56c
- 출처 데이터셋
- uspto-grants-1995_10
- 특허 번호
- US05461048
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