Propionyl chloride → 3-(N-propionyl-N-n-propylamino)chroman

HRID 2210916노트

반응식

HRID 2210916 반응식
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[CH2:6]([NH:9][CH:10]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[O:12][CH2:11]1)[CH2:7][CH3:8]>C(Cl)Cl.[OH-].[Na+]>[C:1]([N:9]([CH:10]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[O:12][CH2:11]1)[CH2:6][CH2:7][CH3:8])(=[O:4])[CH2:2][CH3:3]

참가 물질

5

반응물 2

HCID 62324Propionyl chlorideHCID 195921083-(N-n-propylamino)chroman

생성물 1

HCID 108481013-(N-propionyl-N-n-propylamino)chroman수율 62%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 14798Sodium Hydroxide용매

실험 절차

Propionyl chloride (2.8 g, 29 mmol) was added to a mixture of 15 (1.2 g, 6.4 mmol) in CH2Cl2 and 5% aqueous NaOH. The mixture was stirred for 30 min and separated. The organic layer was extracted with water, separated and dried (MgSO4). The crude product was chromatographed (SiO2) with light petroleum-ether (2:1) as eluant yielding 0.98 g (62%) of 3-(N-propionyl-N-n-propylamino)chroman (16).

후처리

  1. customseparated
  2. extractionThe organic layer was extracted with water
  3. customseparated
  4. dry with materialdried (MgSO4)
  5. customThe crude product was chromatographed (SiO2) with light petroleum-ether (2:1) as eluant

출처 및 근거

ORD 기록
ord-1dc11a9ab68a463984fddff2d546be71
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05461061

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