Hydrochloric Acid → 2-Hydroxy-2-phenylbutyramide

HRID 2211331노트

반응식

HRID 2211331 반응식
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:4])[CH2:2][CH3:3].[OH2:11].[C-:12]#[N:13].[Na+].Cl>C(OCC)C>[OH:4][C:1]([CH2:2][CH3:3])([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:12]([NH2:13])=[O:11]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 71481-Phenyl-1-propanoneHCID 8929Sodium Cyanide

생성물 1

HCID 862302-Hydroxy-2-phenylbutyramide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

In a 1000 ml, two-opening ball matrass equipped with a separating funnel and a thermometer, 89.9 grams (0.67 moles) propiophenone, 100 ml water and 80 ml ethyl ether were added. The matrass was immersed in an ice and salt bath and 82 grams (1.67 moles) granulated sodium cyanide was added. The mixture was shaken vigorously for 20 minutes, and when the mixture temperature had dropped to 5° C., 140 ml (1.7 moles) concentrated hydrochloric acid from the separating funnel was added at such a speed that the temperature of the reaction stayed between 5° C. and 10° C. The addition took nearly two hours.

후처리

  1. customIn a 1000 ml, two-opening ball matrass equipped with a separating funnel
  2. additionwas added
  3. additionwhen the mixture temperature had dropped to 5° C.
  4. customstayed between 5° C. and 10° C
  5. additionThe addition
  6. waittook nearly two hours

출처 및 근거

ORD 기록
ord-362415b806f64a848c243e4a8e1381ef
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05463125

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