Hydrochloric Acid → C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine HCl salt
반응식
C([N:4]1[C:8]2=[N:9][CH:10]=[CH:11][C:12]([CH2:13][NH:14]C(=O)C)=[C:7]2[CH2:6][CH2:5]1)(=O)C.[ClH:18]>CCO>[ClH:18].[NH:4]1[C:8]2=[N:9][CH:10]=[CH:11][C:12]([CH2:13][NH2:14])=[C:7]2[CH2:6][CH2:5]1참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
A mixture of N-(1-acetyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-acetamide (0.50 g, Step A), HCl (conc., 3 mL) and EtOH (12 mL) was heated to 70° C. for overnight. Additional 3 mL of conc. HCl was added to the reaction and the heating was continued for 3 more days. Solvent was evaporated to give a white residue as crude C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine HCl salt, which was used without further purification.
후처리
- customSolvent was evaporated
출처 및 근거
- ORD 기록
- ord-2bd31846089146ac8e4f8934add620d7
- 출처 데이터셋
- uspto-grants-2006_09
- 특허 번호
- US07101868B2
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