Water → HCID 21961313, 화합물

HRID 2211737

반응식

HRID 2211737 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[CH2:12]O)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].P(Br)(Br)[Br:15].O>C(OC(C)C)(C)C>[Br:15][CH2:12]/[CH:11]=[CH:10]/[C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 21961314(2E)-3-[4-(Propan-2-yl)phenyl]prop-2-en-1-ol

생성물 1

HCID 21961313HCID 21961313, 화합물수율 107.4%

시약·촉매·용매 1

HCID 7914Diisopropyl Ether용매

실험 절차

To a solution of (E)-3-(4-isopropylphenyl)-2-propen-1-ol (10.5 g, 59.6 mmol) in isopropyl ether (100 ml) was added under ice cooling phosphorus tribromide(10.7 g, 39.7 mmol) and the resulting mixture was stirred at room temperature for 30 minutes. Water was added into the reaction solution and the product was extracted with isopropyl ether. The organic layer was washed with water and an aqueous saturated solution of sodium hydrogen carbonate, dried on magnesium sulfate, filtered, and then concentrated under reduced pressure to obtain 10.2 g (72% yield) of the oily title compound.

후처리

  1. extractionthe product was extracted with isopropyl ether
  2. washThe organic layer was washed with water
  3. dry with materialan aqueous saturated solution of sodium hydrogen carbonate, dried on magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-97b8197059a944f98cbdfdc98864793e
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101867B2

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