Thionyl Chloride → 5-(Chloromethyl)uracil

HRID 2211817

반응식

HRID 2211817 반응식
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1>O1CCOCC1>[Cl:3][CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 781685-(Hydroxymethyl)uracil

생성물 1

HCID 2361255-(Chloromethyl)uracil수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Thionyl chloride ((10 ml) was added to a suspension of 5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione (0.60 g, 4.2 mmol)from step (11a) in dioxane (15 ml). The reaction was heated to reflux for 4 h, allowed to cool, and concentrated in vacuo to give the 5-(chloromethyl)-2,4(1H,3H)-pyrimidinedione (0.62 g, 100%) as a yellow solid.

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 4 h
  3. temperatureto cool
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7ba52a75ba89449ebaa88639d2057de4
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101883B2

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