2-Benzyl-5-cyanomethyl-2,5-diazabicyclo[2.2.1]heptane → 2-Benzyl-5-(2-aminoethyl)-2,5-diazabicyclo[2.2.1]heptane

HRID 2211854

반응식

HRID 2211854 반응식
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH2:14][CH:9]1[CH2:10][N:11]2[CH2:15][C:16]#[N:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].N>[CH2:1]([N:8]1[CH2:13][CH:12]2[CH2:14][CH:9]1[CH2:10][N:11]2[CH2:15][CH2:16][NH2:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 219636452-Benzyl-5-cyanomethyl-2,5-diazabicyclo[2.2.1]heptane

생성물 1

HCID 219636712-Benzyl-5-(2-aminoethyl)-2,5-diazabicyclo[2.2.1]heptane수율 85.8%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 222Ammonia용매

실험 절차

A solution of 5.74 g (25.3 mmoles) of 140 and 50 mL of NH3 were hydrogenated with 2 g of Raney nickel in a steel autoclave at 100 bar H2 and 100° C. for 2 hours. The catalyst was filtered off with suction and the solution was evaporated and distilled using a bulb tube (boiling point: 135°–145° C. at 0.01 mbar): 5.02 g of 141 as a colorless oil (87% of the theoretical yield).

후처리

  1. filtrationThe catalyst was filtered off with suction
  2. customthe solution was evaporated
  3. distillationdistilled

출처 및 근거

ORD 기록
ord-1e678659166d4c6b89c2e9c645d48a33
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101890B2

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