Hydrochloric Acid → 2H,3H-1lambda6-thieno[2,3-d][1,2]thiazole-1,1,3-trione

HRID 2212238노트

반응식

HRID 2212238 반응식
[S:1]([C:5]1[C:6](C(OC)=O)=[CH:7][S:8][CH:9]=1)(=[O:4])(=[O:3])[NH2:2].[CH3:14][O-:15].[Na+].Cl>CO>[O:4]=[S:1]1(=[O:3])[C:5]2[CH:6]=[CH:7][S:8][C:9]=2[C:14](=[O:15])[NH:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 30422843-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl esterHCID 10942334Sodium Methoxide

생성물 1

HCID 140865502H,3H-1lambda6-thieno[2,3-d][1,2]thiazole-1,1,3-trione

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl 4-sulfamoylthiophene-3-carboxylate (2.7 g, 12.2 mmol), methanol (12 mL), and a 25% methanolic solution of sodium methylate (3.6 mL) was refluxed for 48 h. The reaction mixture was cooled to room temperature and acidified with concentrated hydrochloride acid, and the precipitated product was collected and washed with water. Recrystallized from water, yielded 400 mg of the title compound. MS: 187.8 (M−1), 189.5 (M+1). 1H NMR (DMSO-d6): 8.34 (d, J=4.4 Hz, 1H), 7.705 (d, J=4.8 Hz, 1H).

후처리

  1. customthe precipitated product was collected
  2. washwashed with water
  3. customRecrystallized from water

출처 및 근거

ORD 기록
ord-7b537e2b0847459fa2f532f5b070956c
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101880B2

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