Benzaldehyde → 7-Benzylidene-6,7-dihydro-5H-[1]pyrindine

HRID 2212814

반응식

HRID 2212814 반응식
[N:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(OC(=O)C)(=O)C>>[CH:10](=[C:8]1[C:9]2[N:1]=[CH:2][CH:3]=[CH:4][C:5]=2[CH2:6][CH2:7]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 3

HCID 240BenzaldehydeHCID 7918Acetic AnhydrideHCID 68292Pyrindan

생성물 1

HCID 674163677-Benzylidene-6,7-dihydro-5H-[1]pyrindine수율 75%

실험 절차

15 g (0.125 mol) of 6,7-dihydro-5H-[1]pyrindine, 20.1 g (0.19 mol) of freshly destilled benzaldehyde and 24.5 g (0.24 mol) of acetic acid anhydride were heated under reflux for 24 h. The reaction mixture was evaporated, the residual oil dissolved in methylene chloride, the solution extracted with 1N NaOH solution, and the organic phase dried and evaporated. The residue was destilled under reduced pressure to give 19.3 g (75%) of the title compound.

후처리

  1. temperatureunder reflux for 24 h
  2. customThe reaction mixture was evaporated
  3. dissolutionthe residual oil dissolved in methylene chloride
  4. extractionthe solution extracted with 1N NaOH solution
  5. customthe organic phase dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-b4246cd9d8eb40b4b6de6d466dbf1014
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105513B2

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