Water → tert-Butyl ((1H-benzo[d]imidazol-2-yl)methyl)carbamate

HRID 2213148

반응식

HRID 2213148 반응식
O(C)[Na].[C:4]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])#[N:5].Cl.Cl.[C:17]1(N)[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH2:23].O>CO>[NH:5]1[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]=[C:4]1[CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:13])[CH3:12]

참가 물질

6

반응물 4

HCID 962WaterHCID 119901,2-Phenylenediamine dihydrochlorideHCID 545844tert-butyl N-(cyanomethyl)carbamateHCID 178418582HCID 178418582, 화합물

생성물 1

HCID 11448004tert-Butyl ((1H-benzo[d]imidazol-2-yl)methyl)carbamate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3.32 g of a 30% NaOCH3 solution were added to tert-butyl cyanomethylcarbamate (3 g; 19.21 mmol) in 20 ml of CH3OH, and the mixture was stirred at room temperature for 1 h. After addition of 3.4 g of 1,2-phenylenediamine bishydrochloride, the reaction mixture was stirred further overnight and then added to 100 ml of H2O, and the resulting solid was filtered off and dried in vacuo.

후처리

  1. stirringthe reaction mixture was stirred further overnight
  2. filtrationthe resulting solid was filtered off
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-dbbdafbfa47c4854b58d80974b580e8b
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105508B1

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