참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,3-Diaminopyridine | HCID 9956 | — |
| 반응물 | N-Acetyl-L-Cysteine | HCID 12035 | — |
| 반응물 | tert-butyl N-(cyanomethyl)carbamate | HCID 545844 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | tert-Butyl ((1H-imidazo[4,5-b]pyridin-2-yl)methyl)carbamate | HCID 178453115 | 87.8% |
반응 단계
A mixture of tert-butyl cyanomethylcarbamate (1.61 g; 10 mmol), 2,3-diaminopyridine (0.56 g; 5 mmol), N-acetylcysteine (1.68 g; 10 mmol) in 10 ml of CH3OH was heated at 50° C. for 89 h. It was then concentrated, and the residue was taken up in a little CH3OH and filtered through an acidic ion exchanger (acetate on polymeric support). Renewed concentration and chromatography on silica gel (CH2Cl2/CH3OH 5%) afforded 1.09 g of the required product;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07105508B1 |
|---|
| 출처 데이터셋 | uspto-grants-2006_09 |
|---|
| ORD ID | ord-c8b53dbe03cc4e3eb75c8e152d878f09 |
|---|
| 출처 메모 | uspto-grants-2006_09 |
|---|
