4-Acetylpyridine → 4-(2,4-Dioxo-4-pyridin-4-ylbutoxy)piperidine-1-carboxylic acid tert-butyl ester

HRID 221353

반응식

HRID 221353 반응식
[C:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([O:23][CH2:24][C:25](O)=[O:26])[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>>[C:10]([O:14][C:15]([N:17]1[CH2:18][CH2:19][CH:20]([O:23][CH2:24][C:25](=[O:26])[CH2:2][C:1](=[O:3])[C:4]2[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=2)[CH2:21][CH2:22]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]

참가 물질

3

반응물 2

HCID 142824-AcetylpyridineHCID 15020822-((1-((Tert-butoxy)carbonyl)piperidin-4-yl)oxy)acetic acid

생성물 1

HCID 579544454-(2,4-Dioxo-4-pyridin-4-ylbutoxy)piperidine-1-carboxylic acid tert-butyl ester

실험 절차

Condensation of 4-acetylpyridine with 4-carboxymethoxypiperidine-1-carboxylic acid tert-butyl ester (Preparation 1), employing the protocol described in Preparation 22, afforded the title compound: m/z (ES+)=263.2 [M-Boc+H]+.

후처리

  1. customdescribed in Preparation 22

출처 및 근거

ORD 기록
ord-4722c3c8e618440fbf5e176229b823ec
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207147B2

연결된 노트

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