Water → HCID 21957948, 화합물

HRID 2213591노트

반응식

HRID 2213591 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=O)[CH3:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[H-].[Na+].[CH2:16](Br)[CH2:17]CC.O>CN(C)C=O>[CH2:11]([NH:10][C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1)[CH2:12][CH2:16][CH3:17]

참가 물질

6

반응물 4

HCID 962WaterHCID 8002Butyl bromideHCID 24758Sodium hydrideHCID 258025N-[4-(Propan-2-yl)phenyl]ethanimidic acid

생성물 1

HCID 21957948HCID 21957948, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of N-(4-isopropylphenyl)acetamide (1.8 g) in dimethylformamide (18 mL) was added, under ice-cooling, 60% sodium hydride (0.44 g). Further, butyl bromide (1.4 mL) was added and the mixture was stirred overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed, dried and concentrated under reduced pressure. 4N Hydrochloric acid (13 mL) was added to the residue and the mixture was refluxed for 7 hr. Water was added to the reaction mixture followed by neutralization and the mixture was extracted with ethyl acetate. The organic layer was washed, dried and concentrated under reduced pressure to give butyl(4-isopropylphenyl)amine (1.8 g).

후처리

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. addition4N Hydrochloric acid (13 mL) was added to the residue
  7. temperaturethe mixture was refluxed for 7 hr
  8. additionWater was added to the reaction mixture
  9. extractionthe mixture was extracted with ethyl acetate
  10. washThe organic layer was washed
  11. customdried
  12. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ecdafcd2ed5b4599974a2b4e68310f25
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105567B2

반응 노트

불러오는 중…