2,4-Dichloroaniline → 4-(2,4-Dichloroanilino)-7-methoxybenzo[g]quinoline-3-carbonitrile

HRID 2213789

반응식

HRID 2213789 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[H-].[Na+].Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:20]=3[CH:21]=2)[N:16]=[CH:15][C:14]=1[C:29]#[N:30]>CN(C=O)C>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:13]1[C:22]2[C:17](=[CH:18][C:19]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:20]=3[CH:21]=2)[N:16]=[CH:15][C:14]=1[C:29]#[N:30]

참가 물질

5

반응물 3

HCID 111232,4-DichloroanilineHCID 24758Sodium hydrideHCID 98351404-Chloro-7-methoxybenzo[g]quinoline-3-carbonitrile

생성물 1

HCID 219563924-(2,4-Dichloroanilino)-7-methoxybenzo[g]quinoline-3-carbonitrile수율 86.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to the procedure of Example 14, a reaction mixture of 657.8 mg (4.06 mmol) of 2,4-dichloroaniline and 162.4 mg (4.06 mmol) of sodium hydride in 18 mL of anhydrous DMF is stirred at room temperature for 0.5 hour. To the mixture is added 494.0 mg (1.84 mmol) of 4-chloro-7-methoxybenzo[g]quinoline-3-carbonitrile. The resulting mixture is heated at 55° C. for 1 hour. After work up, 624.6 mg (86.2%) of 4-(2,4-dichloroanilino)-7-methoxybenzo[g]quinoline-3-carbonitrile is obtained as a yellow solid, mp 215–217° C.

후처리

  1. temperatureThe resulting mixture is heated at 55° C. for 1 hour

출처 및 근거

ORD 기록
ord-6e7ea2a547484294a6ca20d6d8ae6d07
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105531B2

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