Potassium Carbonate → Acetic acid, 2-(4-acetyl-2-methylphenoxy)-, methyl ester

HRID 2214

반응식

HRID 2214 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].Br[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:8]([C:6]1[CH:5]=[CH:4][C:3]([O:11][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[C:2]([CH3:1])[CH:7]=1)(=[O:9])[CH3:10]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 701354'-Hydroxy-3'-methylacetophenone

생성물 1

HCID 19261664Acetic acid, 2-(4-acetyl-2-methylphenoxy)-, methyl ester

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4-hydroxy-3-methylacetophenone (5 g), methyl bromoacetate (3.70 ml) and anhydrous potassium carbonate (5.52 g) in acetone (100 ml) was stirred for 66 hours. The mixture was filtered and the filtrate evaporated to give an oil which crystallised on standing giving methyl 4-acetyl-2-methylphenoxyacetate, 7.2 g: m.p. 51°-53° C.; NMR (d6DMSO) δ 7.79 (1H, s), 7.77 (1H, d), 6.94(1H,d), 4.93 (2H, s), 3.71 (3H, s), 2.50 (3H, s+DMSO), 2.24 (3H, s).

후처리

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated
  3. customto give an oil which
  4. customcrystallised

출처 및 근거

ORD 기록
ord-bee4694b03554b1caebf7d486567179e
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728701

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