Water → HCID 13173800, 화합물

HRID 221400

반응식

HRID 221400 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)=[O:4].[CH3:14][C:15]([O-:17])=[O:16].[Na+].O>CC(CC)=O>[C:15]([O:17][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)=[O:4])(=[O:16])[CH3:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-oneHCID 517045Sodium Acetate

생성물 1

HCID 13173800HCID 13173800, 화합물수율 87.5%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

2-Bromo-1-(3-nitrophenyl)ethanone (25 g) was dissolved in methylethyl ketone (150 mL). NaOAc (12.5 g) was added and the mixture stirred for 48 hours. Water (100 mL) was added and the reaction mixture extracted with DCM. The DCM layer was dried over Na2SO4 and concentrated to give the title compound (20 g, 87%).

후처리

  1. extractionthe reaction mixture extracted with DCM
  2. dry with materialThe DCM layer was dried over Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-125495b67b2042a49067997dd3748cf8
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207167B2

연결된 노트

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