Ammonium Chloride → 2-Di-n-propylamino-8-[2[(isopropylideneamino)oxy]benzoyl]-1,2,3,4-tetrahydronaphthalene

HRID 22141

반응식

HRID 22141 반응식
[CH3:1][C:2](=[N:4][OH:5])[CH3:3].CC(C)([O-])C.[K+].[CH2:12]([N:15]([CH2:35][CH2:36][CH3:37])[CH:16]1[CH2:25][CH2:24][C:23]2[C:18](=[C:19]([C:26](=[O:34])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3F)[CH:20]=[CH:21][CH:22]=2)[CH2:17]1)[CH2:13][CH3:14].[Cl-].[NH4+]>C1COCC1>[CH2:35]([N:15]([CH2:12][CH2:13][CH3:14])[CH:16]1[CH2:25][CH2:24][C:23]2[C:18](=[C:19]([C:26](=[O:34])[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:32]=3[O:5][N:4]=[C:2]([CH3:3])[CH3:1])[CH:20]=[CH:21][CH:22]=2)[CH2:17]1)[CH2:36][CH3:37]

참가 물질

6

반응물 4

HCID 25517Ammonium ChlorideHCID 67180Acetone, oximeHCID 152335372-Di-n-propylamino-8-(2'-fluorobenzoyl)-1,2,3,4-tetrahydronaphthaleneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 233735352-Di-n-propylamino-8-[2[(isopropylideneamino)oxy]benzoyl]-1,2,3,4-tetrahydronaphthalene수율 142%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 47.5 mg of acetone oxime (0.65 mmol) in 25 ml of THF were added 73 mg (0.65 mmol) of potassium t-butoxide. The mixture was stirred at room temperature for one hour after which 210 mg of 2-di-n-propylamino-8-(2'-fluorobenzoyl)-1,2,3,4-tetrahydronaphthalene in THF were added via a syringe. The resulting mixture was refluxed for three hours after which it was cooled and poured into an aqueous solution of ammonium chloride. The mixture then was extracted with either, and the extract was dried and concentrated to obtain 343 mg of 2-di-n-propylamino-8-[2[(isopropylideneamino)oxy]benzoyl]-1,2,3,4-tetrahydronaphthalene.

후처리

  1. additionwere added via a syringe
  2. temperatureThe resulting mixture was refluxed for three hours after which it
  3. temperaturewas cooled
  4. extractionThe mixture then was extracted with either, and the extract
  5. customwas dried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2797a14d786349d188da8e5caf5462a1
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05426226

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