Sodium Carbonate → 2-chloro-5-phenylnicotinonitrile

HRID 2214736노트

반응식

HRID 2214736 반응식
O=[C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][NH:3]1.O=P(Cl)(Cl)[Cl:18].P(Cl)(Cl)(Cl)(Cl)Cl.C(=O)([O-])[O-].[Na+].[Na+]>O>[Cl:18][C:2]1[N:3]=[CH:4][C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][C:7]=1[C:8]#[N:9]

참가 물질

6

반응물 4

HCID 10340Sodium CarbonateHCID 24813Phosphorus oxychlorideHCID 24819Phosphorus pentachlorideHCID 2970612-oxo-5-phenyl-1H-pyridine-3-carbonitrile

생성물 1

HCID 27640432-chloro-5-phenylnicotinonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile (2.50 g, 12.7 mmol) was added to a suspension of POCl3 (1.5 ml) and PCl5 (7.35 g) at room temperature. The suspension was then stirred at reflux for 1 hour. The reaction mixture was cooled to room temperature and added cautiously to iced water. The solution was then adjusted to pH 11 with sodium carbonate and the resulting white solid was filtered, washed with water, then dried in vacuo to afford the title compound as a solid.

후처리

  1. temperatureat reflux for 1 hour
  2. filtrationthe resulting white solid was filtered
  3. washwashed with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-e33cdf740b4a4bb6b8784107dddc4379
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109199B2

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