Phosphorus oxychloride → 5-Bromo-2-chloronicotinonitrile

HRID 2214740

반응식

HRID 2214740 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:9]#[N:10])[C:5](=O)[NH:6][CH:7]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:12].O=P(Cl)(Cl)Cl>>[Br:1][C:2]1[CH:7]=[N:6][C:5]([Cl:12])=[C:4]([CH:3]=1)[C:9]#[N:10]

참가 물질

4

반응물 3

HCID 24813Phosphorus oxychlorideHCID 24819Phosphorus pentachlorideHCID 72048705-Bromo-2-hydroxypyridine-3-carbonitrile

생성물 1

HCID 219482695-Bromo-2-chloronicotinonitrile

실험 절차

5-Bromo-2-oxo-1,2-dihydro-pyridine-3-carbonitrile (33 g, 166 mmol) was added to a suspension of PCl5 (96.6 g, 464 mmol) in POCl3 (20 ml, 216 mmol). The mixture was stirred at reflux for 3 hours, cooled to room temperature and then poured slowly into ice/water. The resulting solid was fitered, washed with water, and dried in vacuo to afford the title compound.

후처리

  1. temperatureat reflux for 3 hours
  2. washwashed with water
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-fc0eb2507979454893822ed82cb73a52
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109199B2

연결된 노트

불러오는 중…