Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | cis-1-Acetyl-6-(3,5-dimethylpiperazin-1-yl)-5-methoxyindoline | HCID 69664906 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline | HCID 11265480 | 107.1% |
반응 단계
A stirred solution of D2 (1.6 g, 5 mmole) in 2M HCl acid (50 ml) was heated under reflux for 2 h, then allowed to cool, basified with K2CO3 and extracted with DCM. The extract was dried (Na2SO4) and concentrated under vacuum to afford the title compound as a pale orange solid (1.4 g, 100%). MH+ 276.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07109201B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-7ddca317ee804d899f4ca913d4e9e9ca |
| 출처 메모 | uspto-grants-2006_09 |