Hydrochloric Acid → Ethanone,1-[5,6,7,8-tetrahydro-3-(trifluoromethyl)imidazo[1,5-a]pyrazin-1-yl]-

HRID 221482노트

반응식

HRID 221482 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]2[C:14]([C:20]([F:23])([F:22])[F:21])=[N:15][C:16]([C:17](=[O:19])[CH3:18])=[C:10]2[CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[F:23][C:20]([F:21])([F:22])[C:14]1[N:11]2[CH2:12][CH2:13][NH:8][CH2:9][C:10]2=[C:16]([C:17](=[O:19])[CH3:18])[N:15]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 575184551-acetyl-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

생성물 1

HCID 57518456Ethanone,1-[5,6,7,8-tetrahydro-3-(trifluoromethyl)imidazo[1,5-a]pyrazin-1-yl]-

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

1-Acetyl-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester 27f (0.24 g, 0.72 mmol) was dissolved in a little ethyl acetate. A solution of 2.7 N hydrochloric acid in 5 mL of ethyl acetate was then added. The reaction mixture was reacted at room temperature and monitored by thin layer chromatography until the disappearance of the starting materials. The reaction mixture was concentrated under reduced pressure to obtain the title compound 1-(3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazin-1-yl)-ethanone 27g, which was directly used in the next step.

후처리

  1. customThe reaction mixture was reacted at room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e24336271f6b42caa0cc9355637bac6b
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207161B2

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