Isobutyl chloroformate → [1,2,3]Thiadiazolo[5,4-b]pyridin-6-ylmethanol

반응식

[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[C:7]([C:10](O)=[O:11])[CH:8]=2)[S:3][N:2]=1.C(OC(Cl)=O)C(C)C.[BH4-].[Na+]>>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[C:7]([CH2:10][OH:11])[CH:8]=2)[S:3][N:2]=1

참가 물질

반응물 3

HCID 62365Isobutyl chloroformate

HCID 4311764Sodium borohydride

HCID 21873749[1,2,3]Thiadiazolo[5,4-b]pyridine-6-carboxylic acid

생성물 1

HCID 21873601[1,2,3]Thiadiazolo[5,4-b]pyridin-6-ylmethanol수율 15.9%

실험 절차

The carboxylic acid (iii) (0.82 g) was reacted with isobutylchloroformate and sodium borohydride to afford a semi-solid (0.12 g), after chromatography on silica gel (chloroform).

출처 및 근거

ORD 기록: ord-62bb8549b0bb404db31e93d18de99b8c
출처 데이터셋: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07109213B2

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