Hydrochloric Acid → NPSP795

HRID 2215279노트

반응식

HRID 2215279 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:5][C:4]=1[O:14][CH2:15][C@H:16]([OH:32])[CH2:17][NH:18][C:19]([CH3:31])([CH3:30])[CH2:20][CH:21]1[CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22]1)#[N:2].[ClH:33]>C(#N)C.CCOCC>[ClH:33].[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:5][C:4]=1[O:14][CH2:15][C@H:16]([OH:32])[CH2:17][NH:18][C:19]([CH3:30])([CH3:31])[CH2:20][CH:21]1[CH2:22][C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:29]1)#[N:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 9910902SB-423562

생성물 1

HCID 68607251NPSP795수율 94%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6342Acetonitrile용매

실험 절차

The compound from Example 4 (80 mg, 0.18 mmol) was suspended in acetonitrile (8 mL) and treated with 1 N hydrogen chloride in ether dropwise with stirring until the solid dissolved. The mixture was quickly filtered and cooled in an ice bath. The white crystalline solid which formed was isolated by filtration, washed with ether, and dried in vacuo to afford the title compound (80 mg, 94%). Mp 180–181° C.; MS(ES) m/e 437.2 [M+H]+.

후처리

  1. dissolutiondissolved
  2. filtrationThe mixture was quickly filtered
  3. temperaturecooled in an ice bath
  4. customThe white crystalline solid which formed
  5. customwas isolated by filtration
  6. washwashed with ether
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-3564b0f2d4104ec38ab58cd32ac4b9a4
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109238B2

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