Sodium Hydroxide → 3-(4-Cyano-3-hydroxy-phenyl)-propionic acid
반응식
C([O:3][C:4](=[O:16])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[C:9]([OH:15])[CH:8]=1)C.[OH-].[Na+]>C(O)C.O>[C:13]([C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:16])=[O:3])=[CH:8][C:9]=1[OH:15])#[N:14]참가 물질
5
실험 절차
A solution of 3-(4-Cyano-3-hydroxy-phenyl)-propionic acid ethyl ester (2.2 g, 10 mmol) in ethanol (10 mL) and water (40 mL) was treated with aqueous sodium hydroxide solution (2.5 M, 44 mL) at room temperature overnight. The solvent was removed under vacuum and the residue was dissolved in water (150 mL). The pH of the aqueous solution was adjusted to 2–4 by the addition of 3N HCl (aqueous) and the precipitate was then filtered and washed with water to give the title compound as white solid (1.88 g, 0.98 mmol, 98.4% yield). ESMS m/z: 192 [M+H]+.
후처리
- customThe solvent was removed under vacuum
- dissolutionthe residue was dissolved in water (150 mL)
- additionThe pH of the aqueous solution was adjusted to 2–4 by the addition of 3N HCl (aqueous)
- filtrationthe precipitate was then filtered
- washwashed with water
출처 및 근거
- ORD 기록
- ord-bc4df98abb674dae8f045995e3eb0883
- 출처 데이터셋
- uspto-grants-2006_09
- 특허 번호
- US07109238B2
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