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Hydrochloric Acid → 2-(1,5-dimethyl-1H-indol-7-yl)-N-[2-(6-fluoro-1H-indol-3-yl)-acetyl]-2-oxo-acetamide

HRID 2215786
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HRID 2215786 반응식
CO[C:3](=[O:17])[C:4]([C:6]1[CH:7]=[C:8]([CH3:16])[CH:9]=[C:10]2[C:14]=1[N:13]([CH3:15])[CH:12]=[CH:11]2)=[O:5].[F:18][C:19]1[CH:27]=[C:26]2[C:22]([C:23]([CH2:28][C:29]([NH2:31])=[O:30])=[CH:24][NH:25]2)=[CH:21][CH:20]=1.CC(C)([O-])C.[K+].C1COCC1.Cl>CN(C=O)C>[CH3:15][N:13]1[C:14]2[C:10](=[CH:9][C:8]([CH3:16])=[CH:7][C:6]=2[C:4](=[O:5])[C:3]([NH:31][C:29](=[O:30])[CH2:28][C:23]2[C:22]3[C:26](=[CH:27][C:19]([F:18])=[CH:20][CH:21]=3)[NH:25][CH:24]=2)=[O:17])[CH:11]=[CH:12]1
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반응물 5

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 219500622-(6-fluoro-1H-indol-3-yl)acetamideHCID 23665647Potassium tert-butoxideHCID 69642519(1,5-dimethyl-1H-indol-7-yl)-oxo-acetic acid methyl ester

생성물 1

HCID 219500012-(1,5-dimethyl-1H-indol-7-yl)-N-[2-(6-fluoro-1H-indol-3-yl)-acetyl]-2-oxo-acetamide
수율 23%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of (1,5-dimethyl-1H-indol-7-yl)-oxo-acetic acid methyl ester (0.51 g, 2.21 mmol) and 2-(6-fluoro-1H-indol-3-yl)-acetamide (0.38 g, 2 mmol) in DMF (20 mL) was added a solution of potassium tert-butoxide in THF (1.0 M, 8.0 mL, 8.0 mmol) at room temperature. The reaction mixture was stirred at room temperature for 11 h, treated with concentrated hydrochloric acid (2 mL) and then heated at 50° C. for 2 h. The mixture was cooled to room temperature, extracted with ethyl acetate and the extract was washed with water, saturated aqueous sodium bicarbonate and brine dried (sodium sulfate), filtered and evaporated. Flash column chromatography on silica gel eluting with chloroform and acetone gave 2-(1,5-dimethyl-1H-indol-7-yl)-N-[2-(6-fluoro-1H-indol-3-yl)-acetyl]-2-oxo-acetamide (170 mg, 23%) and 3-(1,5-dimethyl-1H-indol-7-yl)-4-(6-fluoro-1H-indol-3-yl)-pyyrole-2,5-dione (340 mg, 45.5%). 1H NMR (d6-DMSO, 400 MHz) δ 2.26 (s, 3H), 3.58 (s, 3H), 6.36 (d, J=3.13 Hz, 1H), 6.40˜6.45 (m, 2H), 6.73 (s, 1H), 7.11 (dd, J1=2.34 Hz, J2=9.38 Hz, 1H), 7.16 (d, J=3.13 Hz, 1H), 7.7.39 (s, 1H), 7.80 (d, J=3.13 Hz, 1H), 11.14 (s, 1H), 11.82 (s, 1H); MS (ES, m/z): C22H16FN3O2: 374.2 (M++1); 372.2 (M+−1).

후처리

  1. temperatureheated at 50° C. for 2 h
  2. temperatureThe mixture was cooled to room temperature
  3. extractionextracted with ethyl acetate
  4. washthe extract was washed with water, saturated aqueous sodium bicarbonate and brine
  5. dry with materialdried (sodium sulfate)
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-40f619fe98774388be2ec1cdfcb8efb7
출처 데이터셋
uspto-grants-2006_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07109229B2

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