Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 11beta-Methoxy-3-triethylsilyloxy-estra-1,3,5(10),16-tetraene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Silane, bromotriethyl- | HCID 70680 | — |
| 반응물 | 11beta-Methoxy-estra-1,3,5(10),16-tetraen-3-ol | HCID 69529888 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | 11beta-Methoxy-3-triethylsilyloxy-estra-1,3,5(10),16-tetraene | HCID 69529296 | — |
반응 단계
284 mg (1 mmol) of 11β-methoxy-estra-1,3,5(10),16-tetraen-3-ol is reacted in 10 ml of tert-butylmethyl ether and 1 ml of pyridine with 0.6 ml of triethylbromosilane. After 1 hour, 30 ml of water is added to the reaction suspension. The organic phase is separated, washed, dried and concentrated by evaporation in a vacuum. The oily product that is thus obtained is used immediately in the next stage (hydroboration). Yield: 380 mg (95% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07109360B1 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-efbeb87e1e2b41fc8d4b3daad033ae6c |
| 출처 메모 | uspto-grants-2006_09 |