Acetic Anhydride → N-(4-Bromo-2-methylphenyl)acetamide

HRID 2216249

반응식

HRID 2216249 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1.C([O-])(=O)C.[Na+]>C1(C)C=CC=CC=1.C(OCC)(=O)C>[CH3:16][C:11]1[CH:10]=[C:9]([Br:8])[CH:15]=[CH:14][C:12]=1[NH:13][C:5]([CH3:6])=[O:7]

참가 물질

6

반응물 3

HCID 7918Acetic AnhydrideHCID 114234-Bromo-2-methylanilineHCID 517045Sodium Acetate

생성물 1

HCID 222277N-(4-Bromo-2-methylphenyl)acetamide수율 99.9%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8857Ethyl Acetate용매

반응 조건

온도
85 °C

실험 절차

Acetic anhydride (15.2 ml, 0.16 mol) was added dropwise to a stirred mixture of 4-bromo-2-methylaniline (10.0 g, 0.054 mol) and sodium acetate (2.52 g, 0.056 mol) in toluene (150 ml). Once the addition was complete the mixture was warmed to 85° C. and stirred for 40 minutes. The mixture was cooled to room temperature, diluted with ethyl acetate and washed with water. The organic solution was evaporated in vacuo, a further quantity of toluene was added and then the solvent was evaporated to give 4-bromo-2-methylacetanilide (12.3 g), as a colourless solid.

후처리

  1. additionOnce the addition
  2. temperatureThe mixture was cooled to room temperature
  3. washwashed with water
  4. customThe organic solution was evaporated in vacuo
  5. additiona further quantity of toluene was added
  6. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-469f6efd7aa8437e88791e175f260172
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07112553B1

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