Hydrochloric Acid → (3R)-4-nitrosothiomorpholine-3-carboxylic acid

HRID 2216571

반응식

HRID 2216571 반응식
[N:1]([O-:3])=O.[Na+].Cl.[NH:6]1[CH2:11][CH2:10][S:9][CH2:8][C@H:7]1[C:12]([OH:14])=[O:13]>>[N:1]([N:6]1[CH2:11][CH2:10][S:9][CH2:8][C@H:7]1[C:12]([OH:14])=[O:13])=[O:3]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 1152541(R)-thiomorpholine-3-carboxylic acidHCID 23668193Sodium Nitrite

생성물 1

HCID 58700709(3R)-4-nitrosothiomorpholine-3-carboxylic acid

실험 절차

NaNO2 (3.14 g) was added to the 1 mol/L HCl (33.7 mL) solution of (3R)-thiomorpholine-3-carboxylic acid (4.96 g) under a nitrogen atmosphere at 0° C. and stirred for 0.5 h. The solution was extracted with CHCl3 (5 times) and the organic layer was washed with brine. The mixture was dried over MgSO4 and concentrated under reduced pressure to afford crude (3R)-4-nitrosothiomorpholine-3-carboxylic acid as pale yellow crystals.

후처리

  1. extractionThe solution was extracted with CHCl3 (5 times)
  2. washthe organic layer was washed with brine
  3. dry with materialThe mixture was dried over MgSO4
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6c5a4ce6acbf4c78a424c754513ae889
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07112582B2

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