Iodine → HCID 49796119, 화합물

HRID 2217324노트

반응식

HRID 2217324 반응식
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[NH2:11][C:12]([NH2:14])=[S:13].[I:15]I>>[IH:15].[S:13]1[C:2]2[CH2:3][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=3[C:1]=2[N:11]=[C:12]1[NH2:14]

참가 물질

4

반응물 3

HCID 807IodineHCID 67351-IndanoneHCID 2723790Thiourea

생성물 1

HCID 49796119HCID 49796119, 화합물수율 63.6%

반응 조건

온도
95 °C

실험 절차

A mixture of 1-indanone (6.00 g; 45.4 mmol), thiourea (6.92 g; 90.8 mmol) and iodine (11.52 g; 45.4 mmol) was heated to 95° C. with stirring. After 3 hours, the mixture was allowed to cool to room temperature. The crude solid was triturated with absolute ethanol and filtered. The light yellow solid was washed twice with absolute ethanol then allowed to air dry to provide 9.13 g of 8H-Indeno[1,2-d]thiazol-2-ylamine hydroiodide 1a.

후처리

  1. temperatureto cool to room temperature
  2. customThe crude solid was triturated with absolute ethanol
  3. filtrationfiltered
  4. washThe light yellow solid was washed twice with absolute ethanol
  5. customto air dry

출처 및 근거

ORD 기록
ord-ac00b36fa8e340249cdc3ae5fd4976e4
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07407977B2

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