Sodium Hydroxide → 3-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid

HRID 2217652노트

반응식

HRID 2217652 반응식
C[O:2][C:3](=[O:23])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12](=[O:22])(=[O:21])[N:13]([CH3:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1.[OH-].[Na+]>CO>[CH3:20][N:13]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[S:12]([C:8]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]([OH:23])=[O:2])[CH:11]=[CH:10][CH:9]=1)(=[O:21])=[O:22]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 670195883-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid methyl ester

생성물 1

HCID 670195313-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid수율 94.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid methyl ester (4b) (0.150 g, 0.45 mmol) was suspended in methanol (2 ml), 1 N NaOH solution (1.35 ml, 1.35 mmol) was added and the resultant solution was stirred at ambient temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was acidified with 10% HCl and extracted with ethyl acetate. The organic layer was washed successively with water, saturated NaCl, and dried (Na2SO4). The solvent was removed to give the title compound (0.135 g, 94%).

후처리

  1. customThe reaction mixture was partitioned between ethyl acetate and water
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed successively with water, saturated NaCl
  4. dry with materialdried (Na2SO4)
  5. customThe solvent was removed

출처 및 근거

ORD 기록
ord-50e9d7edea65464cbfb1710c28fea3bb
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07407988B2

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