홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

(3S)-piperidin-3-amine dihydrochloride → HCID 59768630, 화합물

HRID 2217847
노트
인쇄 미리보기

반응식

HRID 2217847 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([NH:14][CH2:15][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:13])=[C:7]([Cl:22])[CH:6]=[CH:5][C:4]=2[N:3]=1.Cl.Cl.[NH:25]1[CH2:30][CH2:29][CH2:28][C@H:27]([NH2:31])[CH2:26]1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(#N)C>[NH2:31][C@H:27]1[CH2:28][CH2:29][CH2:30][N:25]([C:2]2[CH:11]=[CH:10][C:9]3[C:8]([C:12]([NH:14][CH2:15][CH:16]4[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]4)=[O:13])=[C:7]([Cl:22])[CH:6]=[CH:5][C:4]=3[N:3]=2)[CH2:26]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 16218278(3S)-piperidin-3-amine dihydrochlorideHCID 860130222,6-dichloro-N-(cyclohexylmethyl)-5-quinolinecarboxamide

생성물 1

HCID 59768630HCID 59768630, 화합물수율 40.4%

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 6342Acetonitrile용매

반응 조건

온도
130 °C

실험 절차

A stirred suspension of 2,6-dichloro-N-(cyclohexylmethyl)quinoline-5-carboxamide (Example 43(a)) (250 mg), (3S)-3-piperidinamine dihydrochloride (260 mg) and tetrabutylammonium bromide (20 mg) in acetonitrile (2 mL) was heated at 130° C. in a microwave for 90 minutes after which it was cooled to room temperature and concentrated. The residue was purified by chromatography (SiO2, dichloromethane:methanol:ammonia in methanol (7 M) 96:3:1 as eluant) and subsequent recrystallisation (acetonitrile) gave the title compound as a solid (120 mg).

후처리

  1. temperaturewas cooled to room temperature
  2. concentrationconcentrated
  3. customThe residue was purified by chromatography (SiO2, dichloromethane:methanol:ammonia in methanol (7 M) 96:3:1 as eluant) and subsequent recrystallisation (acetonitrile)

출처 및 근거

ORD 기록
ord-98d1725d0f1f423fa1488e031f35f95e
출처 데이터셋
uspto-grants-2008_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07408065B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트