Hydrochloric Acid → N-[6-Chloro-2-[(3S)-3-[(2-hydroxyethyl)amino]-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide

HRID 2217858노트

반응식

HRID 2217858 반응식
[Cl:1][C:2]1[C:3]([NH:29][C:30](=[O:38])[CH2:31][CH:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:17][CH2:16][CH2:15][C@H:14]([NH:18][CH2:19][CH2:20][O:21][Si](C(C)(C)C)(C)C)[CH2:13]1)[CH:6]=[CH:5]2.Cl>O1CCOCC1>[Cl:1][C:2]1[C:3]([NH:29][C:30](=[O:38])[CH2:31][CH:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:17][CH2:16][CH2:15][C@H:14]([NH:18][CH2:19][CH2:20][OH:21])[CH2:13]1)[CH:6]=[CH:5]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68808571N-[6-Chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide

생성물 1

HCID 11385256N-[6-Chloro-2-[(3S)-3-[(2-hydroxyethyl)amino]-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide수율 35.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Prepared according to the method of example 50(b), using N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide (Example 61(a)) (200 mg) and 4M hydrogen chloride in 1,4-dioxane (2 mL). Purification (SiO2, methanol:dichloromethane 5:95 as eluant) gave the title compound as a solid (56 mg).

후처리

  1. customPrepared
  2. customPurification (SiO2, methanol:dichloromethane 5:95 as eluant)

출처 및 근거

ORD 기록
ord-095545e3ad7247be986242ec03a56088
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07408065B2

반응 노트

불러오는 중…