2-(1-Methylcyclohexyl)acetic acid → 1-[6-Chloro-5-[[(1-methylcyclohexyl)acetyl]amino]-2-quinolinyl]-4-piperidinecarboxylic acid, ethyl ester

HRID 2217883

반응식

HRID 2217883 반응식
[CH3:1][C:2]1([CH2:8][C:9]([OH:11])=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[NH2:12][C:13]1[C:22]([Cl:23])=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][C:17]([N:24]1[CH2:29][CH2:28][CH:27]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:26][CH2:25]1)=[N:18]2>>[Cl:23][C:22]1[C:13]([NH:12][C:9](=[O:11])[CH2:8][C:2]2([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]2)=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[C:17]([N:24]1[CH2:25][CH2:26][CH:27]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:28][CH2:29]1)[CH:16]=[CH:15]2

참가 물질

3

반응물 2

HCID 136978852-(1-Methylcyclohexyl)acetic acidHCID 69320002Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate

생성물 1

HCID 866097461-[6-Chloro-5-[[(1-methylcyclohexyl)acetyl]amino]-2-quinolinyl]-4-piperidinecarboxylic acid, ethyl ester수율 70.7%

실험 절차

Prepared according to the method of example 62(a), using 1-methyl-cyclohexaneacetic acid (280 mg) and 1-(5-amino-6-chloro-2-quinolinyl)-4-piperidinecarboxylic acid, ethyl ester (Example 77(a)) (200 mg), to afford the sub-titled compound (200 mg).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-efecbd211baa4771ad7fd3b6864c7b93
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07408065B2

연결된 노트

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