4-Piperidinecarbonitrile hydrochloride → 6-Chloro-2-(4-cyano-1-piperidinyl)-N-(2-cyclohexylethyl)-5-quinolinecarboxamide

HRID 2217916

반응식

HRID 2217916 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([NH:14][CH2:15][CH2:16][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[O:13])=[C:7]([Cl:23])[CH:6]=[CH:5][C:4]=2[N:3]=1.Cl.[C:25]([CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)#[N:26]>>[Cl:23][C:7]1[CH:6]=[CH:5][C:4]2[N:3]=[C:2]([N:30]3[CH2:31][CH2:32][CH:27]([C:25]#[N:26])[CH2:28][CH2:29]3)[CH:11]=[CH:10][C:9]=2[C:8]=1[C:12]([NH:14][CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:13]

참가 물질

3

반응물 2

HCID 227446374-Piperidinecarbonitrile hydrochlorideHCID 860128612,6-Dichloro-N-(2-cyclohexylethyl)-5-quinolinecarboxamide

생성물 1

HCID 688096496-Chloro-2-(4-cyano-1-piperidinyl)-N-(2-cyclohexylethyl)-5-quinolinecarboxamide수율 28.3%

실험 절차

Prepared according to the method of example 51, using 2,6-dichloro-N-(cyclohexylethyl)-5-quinolinecarboxamide (Example 94 (d)) (0.35 g), and 4-cyanopiperidine hydrochloride (0.25 g) to afford the title compound (0.12 g).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-80495ad9d07746538a204bcee4b5025c
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07408065B2

연결된 노트

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