Acetic Anhydride → 3-(4-Nitrophenyl)pyridin-2(1H)-one

반응식

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[N+:12]([O-])[CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(OC(=O)C)(=[O:19])C>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11](=[O:19])[NH:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 45557493-(4-Nitrophenyl)pyridine-1-oxide

생성물 1

HCID 541614103-(4-Nitrophenyl)pyridin-2(1H)-one

실험 절차

3-(4-Nitrophenyl)pyridine-1-oxide (P2, 2.5 g, 11.6 mmol) was stirred at reflux in acetic anhydride (25 mL) for 18 hours, then allowed to cool. The reaction mixture was concentrated and concentrated hydrochloric acid (25 mL) was added. The solution was stirred at reflux for 4 hours, then allowed to cool. The reaction mixture was poured onto ice/water and filtration followed by drying under high vacuum afforded the title compound as a solid.

후처리

temperatureto cool
concentrationThe reaction mixture was concentrated
additionconcentrated hydrochloric acid (25 mL) was added
temperatureat reflux for 4 hours
temperatureto cool
additionThe reaction mixture was poured onto ice/water and filtration
customby drying under high vacuum

출처 및 근거

ORD 기록: ord-b7d47c247a274c1ba22d9494a23fd9e0
출처 데이터셋: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07410984B2

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