Sodium Hydroxide → Sodium 5-({3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}amino)-4-hydroxy-5-oxopentanoate

HRID 2218250노트

반응식

HRID 2218250 반응식
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[C:12]([NH:16][C:17]([CH:19]3[CH2:23][CH2:22][C:21](=[O:24])[O:20]3)=[O:18])[CH:13]=[CH:14][CH:15]=2)[CH:5]=[C:4]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[N:3]=1.[OH-:32].[Na+:33]>CO>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[C:12]([NH:16][C:17](=[O:18])[CH:19]([OH:32])[CH2:23][CH2:22][C:21]([O-:20])=[O:24])[CH:13]=[CH:14][CH:15]=2)[CH:5]=[C:4]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[N:3]=1.[Na+:33]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 135469510HCID 135469510, 화합물

생성물 1

HCID 136114629Sodium 5-({3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}amino)-4-hydroxy-5-oxopentanoate수율 60%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide (0.250 g, 0.603 mmol) in methanol (10 mL) was added dropwise 2N NaOH solution (0.3 mL). After the mixture was stirred for 10 minutes, insoluble solid was filtered off. The filtrate was concentrated under reduced pressure and the residue was crystallized from methanol and ethyl ether. The resulting solid was collected by filtration under an argon atmosphere, washed with ethyl ether, and dried under reduced pressure to give Sodium 5-({3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}amino)-4-hydroxy-5-oxopentanoate as a pale yellow solid (0.165 g, yield 60%).

후처리

  1. filtrationinsoluble solid was filtered off
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe residue was crystallized from methanol and ethyl ether
  4. filtrationThe resulting solid was collected by filtration under an argon atmosphere
  5. washwashed with ethyl ether
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-c7188f09625f48aeb0a8a93e7c9f4126
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07410986B2

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