Hydrochloric Acid → 8-Cyclopropyl-4-ethoxyquinoline-2-carboxylic acid

HRID 2218308노트

반응식

HRID 2218308 반응식
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[C:9]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([C:17]([O:19]C)=[O:18])[CH:5]=1)[CH3:2].Cl>C(Cl)(Cl)Cl.CO>[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[C:9]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([C:17]([OH:19])=[O:18])[CH:5]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57440905Methyl 8-cyclopropyl-4-ethoxyquinoline-2-carboxylate

생성물 1

HCID 574408968-Cyclopropyl-4-ethoxyquinoline-2-carboxylic acid

시약·촉매·용매 1

HCID 21584188Chloroform methanol용매

실험 절차

2.0 mL of 5N NaOHaq was added to a solution of 1.10 g of methyl 4-ethoxy-8-cyclopropylquinoline-2-carboxylate in 5 mL of CHCl3/MeOH (1:1) and the mixture was stirred at room temperature for 3 hr. After the addition of 3.0 mL of 5N HCl aq, the mixture was extracted by CHCl3. The organic layer was washed by satd. brine, dried over NaSO4, then concentrated to afford 4-ethoxy-8-cyclopropylquinoline-2-carboxylic acid as a colorless solid.

후처리

  1. extractionthe mixture was extracted by CHCl3
  2. washThe organic layer was washed by satd
  3. dry with materialbrine, dried over NaSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a18bcf50d9f3427d82b12df6f7607054
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07410976B2

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