Hydrochloric Acid → 4-(Phenoxymethyl)-1,3-thiazol-2-amine

HRID 2218529노트

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HRID 2218529 반응식
[O:1]([CH2:8][C:9]1[N:10]=[C:11]([NH:14]C(=O)C)[S:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C1COCC1>[O:1]([CH2:8][C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 2940526N-[4-(phenoxymethyl)-1,3-thiazol-2-yl]acetamide

생성물 1

HCID 20500284-(Phenoxymethyl)-1,3-thiazol-2-amine수율 106.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

To a solution of N-(4-phenoxymethyl-thiazol-2-yl)-acetamide (40 mg, 0.16 mmol) in THF (2 ml) was added 6N HCl (2 ml). The reaction was heated at 60° C. for 3 hours following by stirring at room temperature overnight and then heated at 60° C. for additional 3 hours. The solution was concentrated to afford 4-phenoxymethyl-thiazol-2-ylamine (HCl salt) as a brown viscous oil (35 mg, 90% ). LC/MS m/z 207.09 (M+1)+; HPLC Rt: 1.137 min

후처리

  1. temperatureheated at 60° C. for additional 3 hours
  2. concentrationThe solution was concentrated

출처 및 근거

ORD 기록
ord-94072ca87f8e4c87bed2721496924297
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07411071B2

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