[4-(4-t-Butylcyclohexyl)-3-(4-butylpiperazin-1-yl)phenyl]methanol → 4-(4-t-Butylcyclohexyl)-3-(4-butylpiperazin-1-yl)benzaldehyde

HRID 2218891

반응식

HRID 2218891 반응식
[C:1]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][C:12]=2[N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:21][CH2:20]2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]>[O-2].[Mn+4].[O-2].C(Cl)(Cl)Cl>[C:1]([CH:5]1[CH2:6][CH2:7][CH:8]([C:11]2[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][C:12]=2[N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:21][CH2:20]2)[CH2:9][CH2:10]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 23142118[4-(4-t-Butylcyclohexyl)-3-(4-butylpiperazin-1-yl)phenyl]methanol

생성물 1

HCID 231425004-(4-t-Butylcyclohexyl)-3-(4-butylpiperazin-1-yl)benzaldehyde수율 85.1%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

A mixture of the crude product of [4-(4-t-butylcyclohexyl)-3-(4-butylpiperazine-1-yl)phenyl]methanol produced in Example (101a) (294 mg), manganese(IV) oxide (1.3 g, 14.95 mmol) and chloroform (15 mL) was refluxed for 40 minutes. The reaction mixture was filtered and insoluble materials were filtered off. The filtrate was concentrated under reduced pressure to give 249 mg of a crude product of the title compound as an ochre oil. This product was directly used without purification for the following reaction.

후처리

  1. temperaturewas refluxed for 40 minutes
  2. filtrationThe reaction mixture was filtered
  3. filtrationinsoluble materials were filtered off
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2ffa55f0ecc34c63807c800fff940747
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07410971B2

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