Benzoyl Peroxide → 4-Bromoethyl-isophthalic acid dimethylester

HRID 2218937노트

반응식

HRID 2218937 반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1C=CC(C)=C(C(O)=O)[CH:5]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:33]N1C(=O)CCC1=O.C[CH2:42][CH2:43][CH2:44][CH2:45][CH3:46].C[CH2:48][O:49][C:50]([CH3:52])=[O:51]>C(Cl)(Cl)(Cl)Cl>[CH3:48][O:49][C:50](=[O:51])[C:52]1[CH:46]=[CH:45][C:44]([CH2:43][CH2:42][Br:33])=[C:4]([C:3]([O:2][CH3:1])=[O:14])[CH:5]=1

참가 물질

6

반응물 4

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 21226206Ethyl acetate hexaneHCID 229994865-(Methoxycarbonyl)-2-methylbenzoic acid

생성물 1

HCID 537536654-Bromoethyl-isophthalic acid dimethylester

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of (4) (0.96 g, 4.61 mmol), dibenzoylperoxide (56 mg, 0.23 mmol) and N-bromosuccinimide (NBS) (0.82 g, 4.61 mmol) in carbon tetrachloride (20 ml) was heated at reflux for 20 hours. After cooling to room temperature and filteration the solvent was evaporated to give a yellow oil. Flash chromatograph: silica, hexane/EtOAc (7:3) afforded the pure compound.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. customfilteration the solvent was evaporated
  4. customto give a yellow oil

출처 및 근거

ORD 기록
ord-6f4713bd9ddb44dd955be17255b13fbc
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07413727B2

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